Abstract: Coal dust wettability affected by various physical and chemical factors.Multiple stepwise regression are able to overcome the muti-collinearity of multi-variable,and can obtain the optimal regression equation,so multiple stepwise regression method are used to study the coal dust wettability affected by industry analysis,elemental analysis and surface oxygenic functional groups with SPSS software.The results show that the most important factor affecting the coal dust wettability is the phenolic hydroxyl content on the coal dust surface and carbon content in coal dust.The complex correlation coefficient for optimal regression equation is 0.943 and the optimal regression equation is θ=35.042-10.780(phenolic hydroxyl)+0.859 W_ad(FC).