Abstract: Based on orthogonal test method, we systematically analyzed the combined effect of mining width, remained width and coal body intensity on the mining subsidence, and the multiple regression formula of the mining subsidence and the factors were obtained by using MATLAB software. The results show that the strip mining subsidence and three factors are significantly related, the order of the effect is that the strip mining width > coal body strength > remained width. And in the case of coal body strength of 1.1 MPa, width of 75 m and remained width of 85 m, the surface subsidence basin can be controlled to become a flat bottom basin, the most conducive to the protection of surface buildings.