Abstract: In order to study the influence of slippage effect and matrix deformation on gas seepage of low permeability coal, based on 8^# coal seam of coal core samples of Yuyang Coal Mine, the gas permeability of coal samples is studied by using four kinds of gas. The results show that: when axle loading, confining pressure and gas pressure is constant, the permeability induced by slippage effect shows △K_He，b＞△K_CH4，b＞△K_N2，b＞△K_CO2，b, and the permeability induced by matrix deformation shows that the stronger adsorbability will cause bigger matrix deformation under the same gas pressure level, namely, △K_He，s＜△K_N2，s＜△K_CH4，s＜△K_CO2，s; the permeability induced by slippage effect (△K_i,b), the permeability induced by matrix deformation (△K_i,s) and the effective permeability (△K_i,g) all represent the nonlinear change with the increase of gas pressure under fixed axial and confining pressure. The relationship between the permeability induced by slippage effect (△K_i,b) and gas pressure can be expressed as △K_i，b=ap^b，and the relationship between the permeability induced by matrix deformation (△K_i,s) and gas pressure can be expressed as △K_i，s=ap²+bp +c，and the relationship between the effective permeability (△K_i,g) and gas pressure can be expressed as △K_i，g=ap^b+bp +c.