Abstract: In this paper, the Glabal Navigation Satellite System (GNSS), sensors and inclinometer are used to monitor slope; contrasting geological exploration data, the quantitative effect of monitoring is analyzed. This method has been well used in Lyuhe Changpo Open-pit Coal Mine. In larger sliding area, comprehensive management measures have been taken, such as changing the river route, cutting slope and reducing load etc., it provides a scientific basis for slope disaster prevention, disaster reduction and disaster management.