Abstract: To explore the distribution about water injection pressure and permeability of coal seam influenced by fluid-structure interaction,mathematical modeling based on generalized Darcy's law and geometric modeling based on the actual situation of 3402 working face in Xin’an Coal Mine are established, and we used COMSOL to solve mathematical model of water infusion influenced by fluid-structure interaction and analyzed the changes of seepage field influenced by strain. At last,we draw a conclusion that the distribution regularities of pore pressure and seepage flow velocity are the maximum in water injection hole and show decrease as ellipse centering on the borehole water injection.And we got the relation between permeability of coal steam and water injection pressure and injection time.