Abstract: The plastic damage constitutive model of coal and rock mass was constructed based on Mole-Coulomb criterion. Using damage variable as transition, coal and rock mass permeability-damage evolution equation was also built. Then, using mining rock mechanics, percolation mechanics and damage mechanics, gas seepage-stress-damage coupling model of mining coal and rock was constructed. Gas seepage-stress-damage coupling calculation program of mining coal and rock by using FLAC^3D was designed. At last, gas seepage behavior under long distance protective layer mining in Guqiao Coal Mine was studied through the established model. Results showed that under influence of mining, permeability coefficient of protected seam was 1 760 times of the original value and gas pressure deduced from 2.8 MPa to 0.6 MPa. Coal and gas outburst hazard was eliminated.