Abstract: In the guidance of accident theory and disaster prevention and control theory, through theoretical analysis and mathematical statistics, causal factors of gas overrun in Zhaozhuang Coal Mine were studied. Impact rules of geological structure, mine pressure on the gas overrun were analyzed. Combined with causal factors of the gas overrun, the development model of gas overrun was established. By constructing the index system of three major factors, such as the gas emission, the ventilation defects and major hidden trouble management, the gas overrun risk prediction model was established in Zhaozhuang Coal Mine based on multi-level index mode, and gas overrun risk assessment system was designed. The field application showed that this system could release the corresponding grade prediction result timely when the dangerous information appeared, it set aside sufficient time for the gas disaster emergency response.