Abstract: For the features of open-pit and underground mining in Antaibao Open-pit Coal Mine. we study the influence of blasting vibration on roadway and slope to scientifically reflect open-pit blasting on slope and roadway and control the harmful effect of blasting. We use LS-DYNA numerical simulation method to analyze the dynamic response of slope and tunnel under different loading to evaluate safety of slope and tunnel in Antaibao Mine under blasting vibration.