Abstract: According to the numerical simulation analysis of different mining sequence relationship of steeply inclined orebody from surface to underground, it is concluded that the destruction and displacement from bottom to top extraction are much smaller than the opposite mining sequence, the maximum ground settlement and displacement reduces more than 20%. The moving direction of deep orebody mining of rock mass slope outside the area is contrary to the slope sliding, which reduces the slope slip, increases the probability of landslides. Once causing a landslide, it is easy to block natural water channel and induce the secondary disasters; therefore, it is necessary to strengthen the mining partition optimization design.