Abstract: Chemical oxygen self-rescuer is a self-help tool for escape in the toxic or hypoxic environment. Its principle is the chemical reaction of exhalant CO₂, H₂O and oxygen generating agent to generate oxygen for people to breathe. However, through summarizing chemical oxygen self-rescuer's structure at home and abroad, we comparatively analyze the influence of different structures of breathing air circuit, exhalant air mode and the structure of oxygen generating tank on agent utilization.