Abstract: Based on upper protective seam mining theory, we explores rock-burst prevention mechanism and effect of upper protective seam mining in uphill and downhill roadway protection coal pillar area of kilometer deep coal mine by using FLAC^2D numerical simulation software, meanwhile makes optimization design of rock-burst prevention in a mine -1025 west downhill deep mining area. The results indicate that rock-burst hazard is very high in the whole uphill and downhill roadway protection coal pillar area; the pressure relief and energy consumption and shock absorption effect of upper protective seam mining is proposed; upper protective seam mining can significantly reduce stress concentration degree and make swelling deformation and plastic failure of protected seam in advance which effectively releases elastic potential energy so that it is not easy to occur rock-burst in the effect of tunneling and mining disturbance, in which the effect of rock-burst prevention in uphill and downhill roadway protection coal pillar area is good.