Abstract: Coal and gas outburst danger coal seam is one of the serious disasters in coal mine mining.This article combined with the specific geologic conditions of a mine in Guizhou, using ratio discriminant, "three zone" discriminant, surrounding rock mass balance method and mathematical statistics method to analyze the upward depressurized mining method in theory. Numerical simulation software of UDEC and FLAC^3D is used to analyze the laws of crack evolution and migration in overlying rock and the stress distribution of protected layer respectively. Comprehensive analysis shows that the mining of lower protective coal layer can relief the pressure of rock and gas in protected coal layer effectively.