Abstract: In order to better cope the serious situation of coal seam spontaneous combustion with the deep exploitation for the coal mine, on the basis of the analysis of fire prevention and extinguishing technology for existing mine, combined with the site actual conditions and coal oxidation test, it proposed fire prevention and extinguishing measures, which took monitoring the local temperature in goaf and index gases as the main method, supplemented by fire prevention grouting and building air leakage prevention insulation wall, and once the danger was found, the high level borehole must be drilled in time, then glue injection must be carried on, finally it optimized the design for various measures. According the practical application in the coal mine, CO gas concentration was among 0 to 21×10^-6 in the return airway and corner, it had achieved good results.