Abstract: In order to reduce the construction difficulty in open-pit mine, it is necessary to make a reasonable selection on the arrangement of the work line. The article proposed six solutions to solve the problem and selected six indicators to establish evaluation index system with the ideal solution. Three kinds of proposals were advanced according to the situation of Heidaigou Open-pit Mine. That is partition horizontal mining programs, partition vertical mining programs, pit layout scheme. Evaluation model was established by selecting the amount of infrastructure, transport distance and other factors. According to efficiency indicators, cost-based indicators were calculated respectively to determine the overall ranking of the alternatives. Finally, it concluded that the adopting partition layout work line will reduce the construction time and the distance of the transportation.