Abstract: Grouting is very common of dealing with adverse geological in engineering, and grouting design parameters mainly depends on engineering experience. For a more accurate relation between grouting parameters and optimized design, establish a mathematical model including number of grouting holes, hole inclination, diffusion radius and grouting length and so on, and carry out the parameters sensitivity analysis. Finally, design 16 grouting holes on inclined shaft full-face, spacing between holes is about 1m, section of the tunnel width is 5.4m and arranged 5 grouting holes, direction of drilling relative to the axis of the tunnel tilt 6°. Practical results showed that the geophysical exploration, drainage experiment, inspection hole experiment and coring reveals a good effect of grouting, and there is no large-scale water gushing in the tunneling process. The above model and parameters design can guarantee a complete waterproof layer be formed in the rock fissures, and greatly reduce the permeability of rock mass and increase strength, which also provide a reliable guarantee for roadway waterproof, especially the roadway under Zhenzhou river.