Abstract: The deformation and destroy of roadway was serious under the action of stress damaging and seepage coupling, in order to solve the support difficult problem of this condition, according to the hydrogeology data and initial supporting project of the second belt roadway of Zhuxianzhuang Coal Mine Ⅱ level, theoretical analysis, numerical simulation and site observation method were applied to study the deformation and destroy mechanism of roadway under the action of stress damaging and seepage coupling, essence of roadway instability is the coupling result of seepage field, stress field and damaging field, the key factor of deformation and destroy of roadway was surround rock eroded by seepage water，meanwhile a comprehensive support technology with lowering pressure and water, grouting in deep and shallow hole, bolt/steel mesh/shotcreting, reversed bottom arch，hollow grouted anchor cable, strong sealing layer and strengthening technology in serious areas was proposed.