Abstract: In this paper, the No.3 coal seam in west area of Panzhuang block was considered as the research object, by using the software COMET3 and combined with the drainage data of CBM well and laboratory test data, the multi-well geologic model was established, and the simulation scheme of well interference was designed, then the main controlling factors of well interference during the multi-well exploration had been discussed. Numerical simulation results showed that well interference greatly accelerated the reduction of reservoir pressure, which made the coalbed methane desorb largely. As a result, the effective desorption area increased, the speed of gas production was accelerated and the total gas production was increased too. Well spacing, permeability and porosity were the main controlling factors of well interference. The smaller the well spacing was, the earlier the well interference occurred, and the stronger the degree of the well interference was. The bigger the permeability was, the better the percolation condition of the reservoir was, the faster the rate of drainage and pressure lowering was and the stronger the degree of the interference was. Porosity had a strong influence on well interference in the earlier stage of well group mining, while it weakened in the later stage. Adsorption constant had little influence on well interference.