Abstract: In view of the construction needs of coal mine safety management system based on risk pre-control, interpretive structural model is used to analyze the organizational guarantee basis of the coal safety management system of risk pre-control, it find out some key factors, including the effectiveness of system-building writing group, the effectiveness of system-building leading group, working mental state of personnel, the effectiveness of company leadership team and the support efforts of the various companies and so on, which affects the organizational foundation of the coal safety management system of risk pre-control. In practical work, mining companies can enhance the management of these key factors as the organizational foundation of the coal safety management system of risk pre-control to improve the organizational foundation of the coal safety management system of risk pre-control.