Abstract: Meiyukou Coal Mine is an old mine, which has been reconstructed twice. With the transfer of the main mining area and the increase of mining depth, mine ventilation system becomes complex, ventilation resistance increases, the ventilation management difficulty increases, the fans joint operation efficiency decreases, and ventilation operation costs rise. To improve the effect of mine ventilation and save ventilation costs, after the comprehensive analysis of existing problems in the mine ventilation system, the transformation project of total return airway pass-through in 406 district of 14^-2# coal seam was put forward. By using Longruan GIS software, the ventilation system network of Meiyukou Coal Mine was calculated and analyzed, which provides theory basis for the transformation project of mining production system and ventilation system.