Abstract: To solve the support problems of 22608 roadway in Guandi Mine which is effected by several dynamic pressure from close distance seams, geomechanical tests is conducted firstly, and the results show that the in-situ stress level of 22608 roadway belongs moderate stress level; the strata of roadway roof is mudstone within 4 m, and joints are fractured, and the average intensity of the strata is 22.65 MPa. Secondly, based on in-situ stress measurements results, the stress distribution and deformation conditions of 22608 roadway effected by several dynamic pressure of close distance seams was analyzed by using the method of numerical simulation. At last, high pre-stressed anchor support in full section of roadway with dynamic pressure in close distance seams were proposed, which achieved good results.