Abstract: Through resistance measuring of Jinyang Coal Mine ventilation system, the study analyzes the resistance distribution of the mine ventilation, and finds out the present ventilation system existing problems including disproportional resistance distribution, aging ventilator and so on; combined with the problems existing in resource integration period, the study fulfills the resource integration mine ventilation system reconstruction through the original roadway optimization and coalescence, diging the new tunnels, replacing the main ventilator and so on, and then puts forward resource integration period overall optimization scheme. Through the structure network calculating operation process to conduct reliability analysis, and on the basis of the mine ventilation safety, the study conducts technology assessment and optimal schemes selection, determines the optimal scheme of ventilation system in mine resource integration period.