Abstract: Selecting mechanical-chemical activated compound method as the activation way of gangue gelled materials production. In order to improve the early strength of filler and meet the requirements of the mining filling material, through plastic sand strength test and laser particle size analysis, the mechanical activation time and chemical activator ratio are determined. Then paper uses SPSS software to found a regression equation for data processing. By analyzing the role of chemical activator with regression equation, it provides certain guidance for the preparation of filler material activator in actual industrial production.