Abstract: In order to effectively control the occurrence of human accidents caused by physical fatigue of miners, in this study, grounded theory is used to construct the index system of influencing factors of miners’ physical fatigue and the questionnaire of miners’ physical fatigue is developed; based on the data of the questionnaire, entropy weighting method is used to explore the influence degree of each index on miners’ physical fatigue, and put forward corresponding safety management promotion strategies; and TOPSIS model is applied to evaluate the physical fatigue of 15 miners randomly selected. The results show that: the physical fatigue of miners is affected by their own condition, work pressure and work environment, among which work pressure is the most important factor; the TOPSIS comprehensive rating model of miners’ physical fatigue can judge the grade of miners’ physical fatigue reasonably and effectively.