Abstract: In order to explore the deformation and change law of open-pit slope affected by fault fracture zone under excavation disturbance, a physical model of open-pit slope excavation was established based on the similarity theory, and physical model simulation experiments were carried out under different excavation conditions, considering the influence of formation lithology, fault, excavation and unloading. The results show that the rock mass excavation will lead to the redistribution of rock mass stress, and the near-slope stress changes greatly. The rock mass in the fault tectonic zone shows non-integral movement under the action of excavation, and the vertical displacement of the lower wall rock mass is larger than that of the upper wall rock mass, which indicates that the rock mass in this area has a tendency to produce relative dislocation along the fault fracture zone under the action of excavation disturbance and self-gravity of the upper wall rock mass.