Abstract: In order to explore the formation mechanism of job burnout of coal mine safety managers, based on the job demand-resource model and grounded theory, the research conducted in-depth interviews with coal mine safety managers, built a JD-R theoretical model of coal mine safety managers’ job burnout and proposed relevant hypotheses. The results show that: among the demographic variables, working age, position and working time will affect job burnout; job demands and role pressure negatively predict job burnout, while job resources and organizational justice positively predict job burnout of coal mine safety managers. The mediating effect of role stress on job demand and job burnout was 0.276, and the mediating effect of organizational justice on job resource and job burnout was -0.365.