Abstract: Taking the dust of a coal mine driving face as the research object, the optimization formulation and performance of highly effective dust suppressant were studied. Through sedimentation experiments, the wetting agent components for optimizing the formula of high-efficiency dust suppressants were determined to be a mixture of 2% TX-100 and 0.5% SDBS solution; by conducting viscosity measurement experiments, the adhesive component for optimizing the formula was determined to be E412; by conducting water retention experiments, the water retention agent component for the optimized formula was determined to be PAAS; through the experiment of measuring the acidity and alkalinity of the dust suppressant solution, it was determined that the pH value of the solution adjusted by PHOS was 6.8; the final research obtained the composition and proportion of the high-efficiency dust suppressant GHY-1 formula for mines. The performance measurement experiment results show that the optimized formula of high-efficiency dust suppressant has a surface tension of 68.15 mN/m, the left and right contact angles are 11.25 ° and 10.85 °, respectively, viscosity value is 0.4 mPa·s, water retention rate is 80.5%, and dust reduction efficiency is 95.3%.